Rad-Immune

The understanding of the immune system is changing the way we treat different types of cancer, and focused radiotherapy is an effective Immuno-sensitiser that can potentiate the ability to fight cancer with technology.

Using the techniques of leading cancer researchers and oncologists, this unique online course teaches professionals about cutting-edge immunotherapies combined with radiation treatment.

The ability of radiotherapy to enhance the antigenicity and adjuvanticity of an irradiated tumour has stimulated interest in its combination with immuno-oncology agents. However, radiotherapy often generates multiple layers of host responses which likely depend on the tumour biology, the immune cell infiltration, and the induction of immunosuppressive signals post-radiotherapy.

Consequently, the translation of preclinical findings to the clinic is more convoluted than anticipated which underscores the need to decipher molecular and cellular mechanisms elicited by radiotherapy.

Here, we review pro-inflammatory and immunosuppressive mechanisms triggered by radiotherapy that impact the outcome of antigen-specific T-cell killing and discuss how radiation-induced immunostimulatory mechanisms can be exploited to reactivate the host’s immune system, especially in the context of immunotherapy and hence catapulting into a new age of “Immuno-Radiotherapy”.

Learning Objective:
The understanding of the immune system is changing the way we treat different types of cancer, and Focused Radiotherapy is an effective immuno-sensitizer that can potentiate the ability to fight cancer with technology. Using the techniques of leading cancer researchers and oncologists, this unique online course teaches professionals about cutting-edge immunotherapies combined with radiation treatment.