Dynamics Of Radiation Oncology




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About The Course

Standard-of-care radiotherapy (RT) doses have been developed as a one-size-fits-all approach designed to maximise tumour control rates across a population. Although this has led to high control rates for head and neck cancer with 66–70 Gy, this is done without considering patient heterogeneity.

Head and neck cancers (HNC) are among the ten most common cancer types worldwide, with an increasing incidence in certain virally driven subtypes. Established risk factors for HNC include tobacco use, alcohol consumption and infection by the human papillomavirus (HPV).

Standard of care treatment options include definitive RT, with or without systemic therapy, or initial surgical resection followed by adjuvant RT, with or without systemic therapy, as needed and based on pathological risk features. The most important biological factors influencing the responses of tumours and normal tissues to radiation therapy.

Therefore, the success or failure of standard clinical radiation treatment are often called the 4 R's (repair, redistribution, repopulation, and reoxygenation).

Course Lessons